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CAS No. 469-59-0 | JERVINE

Name: JERVINE CAS No.469-59-0 MF:C27H39NO3 MW:425.6 Purity:98% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 469-59-0 | JERVINE

Synonyms:Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;

17,23-epoxy-3-hydroxy-,(3-beta,23-beta)-veratraman-11-on;

4’,5’,6,6’,6a,6b,7,7’,7’a,8,11a,11b-hexadecahydro-3-hydroxy-3’,6’,10,11b-tetra;

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one;

Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)-pyridin)-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-

Specification:

ITEMS	SPECIFICATION
CAS	469-59-0
MF	C27H39NO3
MW	425.6
Melting point	242- 244°C
Boiling point	541.31°C
Density	1.18±0.1 g/cm3
Acidity coefficient	14.98±0.70
Color	White
Solubility	Soluble in methanol, 2mg/mL
Form	Solid
Storage condition	−20°C

Biological activity:

Jervine (11-Ketocyclopamine) is an inhibitor of the Hedgehog signaling pathway (IC50=500-700 nM) and inhibits the shh signaling pathway by interacting with smoothened.

Chemical properties:

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Veratrum.

Package and transportation :

Package: 5g,25g,200g,500g,1kg